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function. Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities ... We demonstrate that SIN3A is required for TCDD induction of the CYP1A1 protein in Hepa-1 cells but not for expression of the aryl hydrocarbon receptor protein. Reduction of Sin3A expression by RNA interference specifically inhibits estrogen-induced repression of ESR1. Furthermore, an estrogen-responsive interaction ... Aug 2, 2018 ... Our data suggest that Fam60a is required for proper embryogenesis, at least in part as a result of its regulation of DNA methylation at specific gene promoters. Oct 12, 2018 ... ... Sin3a−Hdac complex, at which point it introduces chemical modifications to the DNA that directly influence whether adjacent genes are ... Sin3A associated protein 30 [Source:HGNC Symbol;Acc:HGNC:10532]. Ensembl ID. ENSG00000164105. Bio databases IDs, NCBI: 8819 Ensembl: ENSG00000164105. Aliases ... Sin3a plays a critical role in the maintenance of Treg identity and function and is essential for the expression and stability of Foxp3. 4 days ago ... SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. Feb 3, 2025 ... ... Sin3a as a novel transcriptional regulator of β-cell mass adaptation. β-Cell–specific Sin3a knockout animals showed profound diabetes due to ... Jul 1, 2014 ... to Sin3A whereas 3-Cl-AHPC exposure decreased the level of. Sin3A protein at 48 h in Western blot (Fig. 4A). Exposure of cells to 3-Cl-AHPC ...