Ứng dụng của sin3a trong xử lý tín hiệu.

Aug 2, 2018 ... Our data suggest that Fam60a is required for proper embryogenesis, at least in part as a result of its regulation of DNA methylation at specific gene promoters. Feb 3, 2025 ... ... Sin3a as a novel transcriptional regulator of β-cell mass adaptation. β-Cell–specific Sin3a knockout animals showed profound diabetes due to ... We demonstrate that SIN3A is required for TCDD induction of the CYP1A1 protein in Hepa-1 cells but not for expression of the aryl hydrocarbon receptor protein. Jun 14, 2019 ... Abstract. STAT3 can mediate epigenetic silencing of tumor suppressor genes (TSG). However, little is known about the molecular mechanisms ... These results demonstrate key functional differences between SIN3 paralogs in regulating the process of breast cancer metastasis. Feb 9, 2024 ... We observe that Sin3A protein is enriched at replicating DNA in the presence of hydroxyurea. In this situation, Sin3A-depleted cells show ... Here, we define a critical role for the corepressor SIN3A in memory and synaptic plasticity, showing that postnatal neuronal deletion of Sin3a enhances ... Protein complexes containing SIN3A act as histone deacetylase (see HDAC1; 601241)-dependent corepressors. SIN3A contains multiple protein-protein ... ... Sin3A corepressor complex and targets Sin3A. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucleic Acids ... Aug 1, 2023 ... SIN3A defects associated with syndromic congenital hypogonadotropic hypogonadism: an overlap with Witteveen-Kolk syndrome.