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Feb 9, 2024 ... We observe that Sin3A protein is enriched at replicating DNA in the presence of hydroxyurea. In this situation, Sin3A-depleted cells show ... Feb 27, 2024 ... Provided the recent observation that the SIN3A histone deacetylase complex reduces transcription-replication conflicts, we explore the role of ... May 8, 2018 ... LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer These results demonstrate key functional differences between SIN3 paralogs in regulating the process of breast cancer metastasis. Here, we define a critical role for the corepressor SIN3A in memory and synaptic plasticity, showing that postnatal neuronal deletion of Sin3a enhances ... May 3, 2013 ... Establishment of this gene variant database (LSDB) was supported by the Leiden University Medical Center (LUMC), Leiden, Nederland. Date created ... Witteveen-Kolk syndrome is a rare neurodevelopmental disorder comprising intellectual disability, developmental delay and dysmorphic facial features ... SIN3A and MAN2C1 resulting in Witteveen-Kolk syndrome ... This deletion is anticipated to result in production of a chimeric SIN3A::MAN2C1 protein which would ... ... Sin3A/Rpd3, via yet unknown mechanisms. Here, we identified Snr1and Mod(mdg4) as essential for dhd expression and investigated how these epigenomiceffectors ... Jan 24, 2025 ... BAHCC1 antagonizes SIN3A histone deacetylation and positively regulates the expression of genes that are important for growth and migration-related processes.
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