Các hệ thống điều khiển có thể sử dụng các tín hiệu sin để điều chỉnh các quá trình.

Recent study has identified that haploinsufficiency of SIN3A (chromosome 15q24.2) is associated with mild syndromic intellectual disability. This phenotype ... Mar 22, 2023 ... pSID co-localizes with Sin3A and interference with PAH2-mediated Sin3A functions by pSID is shown by disruption of Sin3A-MAD1 interactions ... Sin3a deletion in mice causes CDH, lung hypoplasia, defects in cell cycling, and pulmonary hypertension. • Use Sin3a genetic targets as a guide to improve lung ... Oct 12, 2018 ... ... Sin3a−Hdac complex, at which point it introduces chemical modifications to the DNA that directly influence whether adjacent genes are ... Witteveen-Kolk syndrome (WITKOS) is an autosomal dominant disorder with characteristic distinctive facial features, microcephaly, short stature, and mildly ... We demonstrate that SIN3A is required for TCDD induction of the CYP1A1 protein in Hepa-1 cells but not for expression of the aryl hydrocarbon receptor protein. May 25, 2024 ... Gene name - Sin3A. Synonyms - Cytological map position - 49B5-49B7. Function - Transcription factor; Chromatin protein. ▽ Description. SAP130 is a subunit of the histone deacetylase (see HDAC1; 601241)-dependent SIN3A (607776) corepressor complex (Fleischer et al., 2003). HDAC1 activity [29] and the Sin3A complex [30] are also required for full transcriptional activity of interferon-α responsive genes and Nanog promoter, ... Unfollow This Gene ... Click here to learn more about how to cite ClinGen and to see a list of the external resources utilized. The information on this website is ...