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Jan 1, 2018 ... t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid ... Sep 14, 2020 ... In particular, the researchers identified several genes that Sin3a appeared to regulate, including some associated with protein transport, ... Protein complexes containing SIN3A act as histone deacetylase (see HDAC1; 601241)-dependent corepressors. SIN3A contains multiple protein-protein ... Oct 12, 2018 ... ... Sin3a−Hdac complex, at which point it introduces chemical modifications to the DNA that directly influence whether adjacent genes are ... List of variants reported for SIN3A-related intellectual disability syndrome due to a point mutation by St James's Hospital, Trinity College Dublin ... Jul 15, 2015 ... Here, we describe the mechanism of assembly of the mammalian Sin3L/Rpd3L complex facilitated by Sds3, a conserved subunit deemed critical for proper assembly. PA1-870 detects mSin3A from human and mouse tissues and cells. PA1-870 has been successfully used in Western blot, ICC/IF ChIP, IHC-P and immunoprecipitation ... A few children are known to have inherited a pathogenic variant of the SIN3A gene form a mildly affected parent. The risk of having another child affected by a ... Detects human and mouse SIN3A in Western blots. Source: Polyclonal Goat IgG. Purification: Antigen Affinity-purified. Immunogen: E. coli-derived recombinant ... SIN3ASIN3 transcription regulator family member A · SFARI Gene Score · Autism Reports / Total Reports · Rare Variants / Common Variants · Aliases · Associated ...
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