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function. Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities ... Witteveen-Kolk syndrome (WITKOS) is an autosomal dominant disorder with characteristic distinctive facial features, microcephaly, short stature, and mildly ... Reduction of Sin3A expression by RNA interference specifically inhibits estrogen-induced repression of ESR1. Furthermore, an estrogen-responsive interaction ... HDAC1 activity [29] and the Sin3A complex [30] are also required for full transcriptional activity of interferon-α responsive genes and Nanog promoter, ... Dec 10, 2007 ... Covalent modification of histones regulates chromatin structure and gene expression. Sin3A mediates the association of histone deacetylase ... The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia. Jan 12, 2021 ... Abstract. Witteveen-Kolk syndrome (OMIM 613406) is a recently defined neurodevelopmental syndrome caused by heterozygous loss-of-function ... Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal. The EMBO Journal. Sin3a is the central scaffold protein of ... Jun 13, 2020 ... Let c=cos(A), s=sin(A), C=cos(2A), and S=sin(2A). Then. cos(3A)=Cc−Ssandsin(3A)=Sc+sC. so the numerator on the LHS is. Jan 1, 2018 ... t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid ...