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Here, we define a critical role for the corepressor SIN3A in memory and synaptic plasticity, showing that postnatal neuronal deletion of Sin3a enhances ... Jan 24, 2025 ... BAHCC1 antagonizes SIN3A histone deacetylation and positively regulates the expression of genes that are important for growth and migration-related processes. The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia. Aug 1, 2023 ... SIN3A defects associated with syndromic congenital hypogonadotropic hypogonadism: an overlap with Witteveen-Kolk syndrome. Nov 1, 2014 ... ... Sin3A Associated Protein 130 (SAP130). 2. Previous1Next. Citation. Dessen P. SAP130 (Sin3A associated protein 130). Atlas Genet Cytogenet Oncol ... We demonstrate that SIN3A is required for TCDD induction of the CYP1A1 protein in Hepa-1 cells but not for expression of the aryl hydrocarbon receptor protein. Recent study has identified that haploinsufficiency of SIN3A (chromosome 15q24.2) is associated with mild syndromic intellectual disability. This phenotype ... ... SIN3A and MAN2C1 resulting in Witteveen-Kolk syndrome ... This deletion is anticipated to result in production of a chimeric SIN3A::MAN2C1 protein which would ... Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal. The EMBO Journal. Sin3a is the central scaffold protein of ... Witteveen-Kolk syndrome (WITKOS) is an autosomal dominant disorder with characteristic distinctive facial features, microcephaly, short stature, and mildly ...