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May 3, 2013 ... Establishment of this gene variant database (LSDB) was supported by the Leiden University Medical Center (LUMC), Leiden, Nederland. Date created ... Jun 28, 2017 ... Sin3a is a central component of a class of histone deacetylase‐containing transcriptional co‐regulatory complexes. In this issue of The EMBO ... Sin3A Rabbit pAb (A1577) ... US orders can be delivered next day. ... The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of ... Jun 14, 2019 ... Abstract. STAT3 can mediate epigenetic silencing of tumor suppressor genes (TSG). However, little is known about the molecular mechanisms ... ... SIN3A and MAN2C1 resulting in Witteveen-Kolk syndrome ... This deletion is anticipated to result in production of a chimeric SIN3A::MAN2C1 protein which would ... ... Sin3A/Rpd3, via yet unknown mechanisms. Here, we identified Snr1and Mod(mdg4) as essential for dhd expression and investigated how these epigenomiceffectors ... Witteveen-Kolk syndrome is a rare neurodevelopmental disorder comprising intellectual disability, developmental delay and dysmorphic facial features Oct 12, 2018 ... ... Sin3a−Hdac complex, at which point it introduces chemical modifications to the DNA that directly influence whether adjacent genes are ... Witteveen-Kolk syndrome (WITKOS) is an autosomal dominant disorder with characteristic distinctive facial features, microcephaly, short stature, and mildly ... Reduction of Sin3A expression by RNA interference specifically inhibits estrogen-induced repression of ESR1. Furthermore, an estrogen-responsive interaction ...