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Jun 28, 2017 ... Sin3a is a central component of a class of histone deacetylase‐containing transcriptional co‐regulatory complexes. In this issue of The EMBO ... Witteveen-Kolk syndrome is a rare neurodevelopmental disorder comprising intellectual disability, developmental delay and dysmorphic facial features May 25, 2024 ... Gene name - Sin3A. Synonyms - Cytological map position - 49B5-49B7. Function - Transcription factor; Chromatin protein. Sin3a plays a critical role in the maintenance of Treg identity and function and is essential for the expression and stability of Foxp3. Jul 15, 2015 ... Here, we describe the mechanism of assembly of the mammalian Sin3L/Rpd3L complex facilitated by Sds3, a conserved subunit deemed critical for proper assembly. Feb 18, 2020 ... A ) Structure of murine Sin3a locus with exon 4 highlighted. · B ) Sin3aNH mice have decreased SIN3A protein levels (arrows) in the hippocampus ... ... Sin3A, Rab40C, Rad50, and Ube2i were necessary for both AHR expression and ... Sin3A, from which we found that Sin3A physically associates with the 5 ... Feb 9, 2024 ... We observe that Sin3A protein is enriched at replicating DNA in the presence of hydroxyurea. In this situation, Sin3A-depleted cells show ... ... SIN3A and MAN2C1 resulting in Witteveen-Kolk syndrome ... This deletion is anticipated to result in production of a chimeric SIN3A::MAN2C1 protein which would ... Feb 27, 2024 ... Provided the recent observation that the SIN3A histone deacetylase complex reduces transcription-replication conflicts, we explore the role of ...